Self-Collimating SPECT With Multi-Layer Interspaced Mosaic Detectors

Conventional single photon emission computed tomography (SPECT) relies on mechanical collimation whose resolution and sensitivity are interdependent, the best performance a SPECT system can attain is only compromise of these two equally desired properties. To simultaneously achieve high sensitivity, we propose to use sensitive detectors constructed in multi-layer inter spaced mosaicdetectors (MATRICES) architecture accomplish part needed. We name this new approach self-collimation. evaluate three self-collimating systems report their imaging performance: 1) A simulated human brain achieves 3.88% it clearly resolves 0.5-mm 1.0-mm hot-rod patterns at noise-free realistic count-levels, respectively; 2) mouse 1.25% 50-μm 100-μm 3) prototype 0.14% separates 0.3-mm-diameter point sources which center-to-center neighbor distance also 0.3 mm. Simulated contrast phantom studies show excellent signal-to-noise performance. The unprecedented demonstrated by 3 scanners clear manifestation superiority over conventional collimation. It represents potential paradigm shift technology development.